تفاعل #1383378

معادلة التفاعل

2-Amino-1,3-dihydroxypropane

sodium methylate

5-amino-1,3-benzenedicarboxylic acid dimethyl ester

→

5-amino-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-1,3-benzenedicarboxamide

المردود 93.0%

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture is heated to the reflux temperature
2. 2
   أخرىto get a solution
3. 3
   ترشيحis filtered
4. 4
   ترشيحthe solid on filter
5. 5
   غسيلis washed with methanol (40 mL)
6. 6
   أخرىdried
7. 7
   أخرىyielding the product of the title (43.5 g, 133 mmol, yield: 93%)

الإجراء التجريبي

2-Amino-1,3-dihydroxypropane (27.4 g, 300 mmol) and 1.5M solution of sodium methylate in methanol (14.3 mL, 21.5 mmol) are added to a suspension of 5-amino-1,3-benzenedicarboxylic acid dimethyl ester (30.0 g, 143 mmol) in methanol (0.2 L). The reaction mixture is heated to the reflux temperature to get a solution. After 2.5 hours of reflux and 4 hours at room temperature the reaction mixture is filtered and the solid on filter is washed with methanol (40 mL) and dried yielding the product of the title (43.5 g, 133 mmol, yield: 93%).

المصدر