تفاعل #1381467

معادلة التفاعل

methyl 2-[2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyloxy]phenyl]acetate

tetrahydrofuran

Hydrochloric acid

sodium hydroxide

→

2-[2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyloxy]phenyl]acetic acid

المردود 96.0%

المذيبات

methanol

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe precipitated solid was collected by filtration
2. 2
   أخرىdried with air

الإجراء التجريبي

To a mixture of methyl 2-[2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyloxy]phenyl]acetate (0.57 g), tetrahydrofuran (3.0 mL) and methanol (3.0 mL) was added a 1N aqueous sodium hydroxide solution (2.4 mL) and the mixture was stirred at 50° C. for 1.5 hrs. 1N Hydrochloric acid (2.4 mL) and water were added to the reaction mixture, and the precipitated solid was collected by filtration and dried with air to give crystals (0.51 g, 96%) of 2-[2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyloxy]phenyl]acetic acid. Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 141-142° C.

المصدر