تفاعل #1381

معادلة التفاعل

Methyl 2-methyl-3-nitrobenzoate

→

methyl 2-methyl-3-aminobenzoate

المردود 101.6%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   ترشيحthe catalyst is filtered off
3. 3
   تركيزThe reaction mixture is concentrated
4. 4
   workup.ADDITIONis added water
5. 5
   استخلاصfollowed by extraction with dichloromethane
6. 6
   تركيزThe solvent is concentrated

الإجراء التجريبي

Methyl 2-methyl-3-nitrobenzoate (10.0 g) is dissolved in acetic acid (50 ml) and thereto 5% Pd-C (1 g) is added to carry out catalytic reduction at room temperature under 1 atm. After 1.5 hours, the catalyst is filtered off. The reaction mixture is concentrated, and thereto is added water, and the mixture is made alkaline with potassium carbonate, followed by extraction with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-aminobenzoate (8.6 g).

المصدر