تفاعل #1379897

معادلة التفاعل

2-(2-aminoethylamino)ethanol

benzyl acrylate

→

2-(benzyloxycarbonylethyl]-2-(2aminoethylamino)ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 24 hours
3. 3
   أخرىThe excess reagent was removed under reduced pressure
4. 4
   أخرىthe resulting oil was purified by flash chromatography
5. 5
   workup.ADDITIONa mixture of dichloromethane and ethyl acetate (60:40)
6. 6
   غسيلto elute the desired material
7. 7
   أخرىFractions were collected

الإجراء التجريبي

A solution of 2-(2-aminoethylamino)ethanol (4.6648 g; 44.8 mmole) dissolved in 35 mL of benzyl acrylate was heated at reflux for 24 hours. The excess reagent was removed under reduced pressure and the resulting oil was purified by flash chromatography using a mixture of dichloromethane and ethyl acetate (60:40) to elute the desired material. Fractions were collected and analyzed to determine which of these contain the product. Solvents were eliminated under vacuum to give 5.8 g (21.9%) of N,N,N′-tris[2-(benzyloxycarbonylethyl]-2-(2aminoethylamino)ethanol (8).

المصدر