تفاعل #1379892

معادلة التفاعل

2,3-bis-tert-butoxycarbonylamino propionic acid benzyl ester

HCl

→

2,3-Diamino-propionic acid trihydrochloride

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under vacuum
2. 2
   workup.ADDITIONthe mixture was diluted with ethyl acetate (100 ml) and water (50 ml)
3. 3
   أخرىThe layers were separated
4. 4
   أخرىthe aqueous layer was evaporated to dryness (1.23 g of a foam/syrup)

الإجراء التجريبي

A solution of 2,3-bis-tert-butoxycarbonylamino propionic acid benzyl ester (1.8 g), 4N aqueous HCl (40 ml), and acetonitrile (50 ml) was stirred for 18 hours at room temperature. The solvent was removed under vacuum, and the mixture was diluted with ethyl acetate (100 ml) and water (50 ml) and stirred for 15 minutes. The layers were separated and the aqueous layer was evaporated to dryness (1.23 g of a foam/syrup). 1H NMR (300 MHz): 3.2-3.5 (m, 2H), 4.2-4.35 (m, 1H), 5.13-5.25 (q, 2H, J=11.8, 3.1 Hz).

المصدر