تفاعل #1379890
ord-e796985f790a46e48b1f769398221cab
معادلة التفاعل
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1درجة الحرارةat reflux for 48 h
- 2درجة الحرارةto cool to ambient,
- 3استخلاصthe filtrate extracted with diethyl ether (3×100 ml)
- 4أخرىThe precipitate which formed
- 5ترشيحwas collected by filtration
- 6غسيلwashed first with water (200 ml)
- 7تجفيفwith acetone (200 ml) before being dried
الإجراء التجريبي
A mixture of 5-aminoquinoline (9.9 g, 0.069 mol) and crotonic acid (8.9 g, 0.103 mol) in toluene (35 ml) was stirred at reflux for 48 h. The reaction mixture was allowed to cool to ambient, added to water (500 ml) and the pH adjusted to 9 to 10 by the addition of 2N sodium hydroxide. The reaction mixture was screened and the filtrate extracted with diethyl ether (3×100 ml). The pH of the aqueous layer was first adjusted to pH2 with concentrated HCl and then to pH7 with calcium hydroxide. The precipitate which formed was collected by filtration, washed first with water (200 ml) and then with acetone (200 ml) before being dried to give 8.1 g of a cream solid.