تفاعل #1379889

معادلة التفاعل

sodium hydroxide

product

4-(quinolin-5-ylamino)-benzoic Acid Methyl Ester

→

orange powder

4-(quinolin-5-ylamino)-benzoic Acid

المذيبات

water

tetrahydrofuran

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىwas removed under reduced pressure
2. 2
   أخرىThe resultant residue was purified
3. 3
   workup.DISSOLUTIONby dissolving in water (1000 ml)
4. 4
   أخرىprecipitating the crude product by acidification to pH3 with 2N HCl
5. 5
   أخرىThe precipitate so formed
6. 6
   ترشيحwas collected by filtration
7. 7
   غسيلwashed with water (250 ml)
8. 8
   أخرىThis purification procedure
9. 9
   أخرىwas dried

الإجراء التجريبي

A solution of sodium hydroxide (7 g, 0.18 mol) in water (100 ml) was added to a solution of the product from stage (a) in a mixture of tetrahydrofuran (100 ml) and methanol (350 ml). The reaction mixture was stirred at 50° C. for 3 h before the solvent was removed under reduced pressure. The resultant residue was purified by dissolving in water (1000 ml) adjusted to pH10 with 2M NaOH and precipitating the crude product by acidification to pH3 with 2N HCl. The precipitate so formed was collected by filtration and washed with water (250 ml). This purification procedure was repeated a further two times before the product was dried to give 12.3 g of an orange powder.

المصدر