تفاعل #1377508

معادلة التفاعل

Ethyl 2-hydroxyisobutyrate

Diethylaminosulphur trifluoride

→

ethyl 2-fluoro-isobutyrate

المردود 101.4%

المذيبات

methylene chloride

methylene chloride

methylene chloride

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter completion of the addition
2. 2
   درجة الحرارةto warm to room temperature
3. 3
   workup.WAITstood for 3 hours
4. 4
   أخرىovernight
5. 5
   workup.ADDITIONThe reaction was then carefully added to ice with vigorous stirring
6. 6
   استخلاصextract of the aqueous layer
7. 7
   غسيلThe total organic fraction was washed with brine
8. 8
   تجفيفdried over magnesium sulphate
9. 9
   workup.DISTILLATIONthe solvent carefully distilled

الإجراء التجريبي

Ethyl 2-hydroxyisobutyrate (12.43 g) was stirred in dry methylene chloride (65 ml) at -70° C. under nitrogen. Diethylaminosulphur trifluoride (30.32 g) in dry methylene chloride (5 ml) was added slowly, maintaining the temperature at -70° C. After completion of the addition, the mixture was stirred at -70° C. for 1 hour and was then allowed to warm to room temperature, stood for 3 hours and then overnight. The reaction was then carefully added to ice with vigorous stirring, and the resultant methylene chloride layer combined with a further methylene chloride extract of the aqueous layer. The total organic fraction was washed with brine, dried over magnesium sulphate and the solvent carefully distilled, to leave ethyl 2-fluoro-isobutyrate as a bronze liquid (12.8 g); 1H NMR analysis indicated that this material was >95% pure, and contained 2-3% of ethyl methacrylate. NMR (CDCl3, 270 MHz) δ 1.31(3H,t), 1.58(6H,d), 4.25(2H,q) ppm; 1H NMR (CDCl3, 254 MHz, 19F) δ -148.0 (1F, septet) ppm.

المصدر