تفاعل #1371

معادلة التفاعل

diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

p-toluenesulfonic acid

→

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

المردود 82.6%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture is refluxed for 2.5 hours
2. 2
   درجة الحرارةAfter cooling
3. 3
   استخلاصthe resultant is extracted with diethyl ether
4. 4
   تجفيفthe extract is dried over magnesium sulfate
5. 5
   تركيزconcentrated

الإجراء التجريبي

To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).

المصدر