تفاعل #1362792

معادلة التفاعل

methyl 4-iodobenzoate

5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthol

sodium hydride

→

methyl 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyloxy)benzoate

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added in small amounts
2. 2
   درجة الحرارةthe resulting mixture was heated
3. 3
   درجة الحرارةat reflux for 16 hours
4. 4
   أخرىThe reaction medium was evaporated to dryness
5. 5
   أخرىethyl ether, the organic phase decanted off
6. 6
   تجفيفdried over magnesium sulfate
7. 7
   أخرىevaporated

الإجراء التجريبي

5.3 g (15 mmol) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthol and 70 ml of pyridine were introduced into a three-necked flask under a nitrogen stream, and 430 mg (15 mmol) of sodium hydride (80% in oil) were added in small amounts. The mixture was stirred for 30 minutes, 3.9 g (15 mmol) of methyl 4-iodobenzoate and 4.6 g (22.5 mmol) of a copper bromide and dimethyl sulfide complex were added successively and the resulting mixture was heated at reflux for 16 hours. The reaction medium was evaporated to dryness, taken up in water and ethyl ether, the organic phase decanted off, dried over magnesium sulfate and evaporated.

المصدر