تفاعل #1362656

معادلة التفاعل

potassium carbonate

1-ethyl-5-hydroxypyrazole

N,N'-dicyclohexylcarbodiimide

4-hydroxy-6-carboxy-5-methylthiochroman-1,1-dioxide

→

4-hydroxy-5-methyl-6-(1-ethyl-5-hydroxypyrazol-4-yl)carbonylthiochroman-1,1-dioxide

المردود 73.2%

المذيبات

t-amyl alcohol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was heated at 80° C. for 6 hours
2. 2
   أخرىAfter the completion of the reaction
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   workup.DISSOLUTIONThe remaining oil was dissolved in ethyl acetate
5. 5
   استخلاصend product was extracted with a 5 wt % sodium hydrogencarbonate aqueous solution
6. 6
   أخرىThe resultant aqueous solution was adjusted to a pH of 1 in an ice bath
7. 7
   workup.ADDITIONby adding 2N hydrochloric acid
8. 8
   استخلاصextracted with ethyl acetate
9. 9
   غسيلAn organic layer was washed with a saturated sodium chloride aqueous solution
10. 10
    تجفيفdried over anhydrous sodium sulfate
11. 11
    workup.DISTILLATIONthe solvent was distilled off

الإجراء التجريبي

2.0 Grams (7.8 mmol) of 4-hydroxy-6-carboxy-5-methylthiochroman-1,1-dioxide was dissolved in 10 ml of t-amyl alcohol, and 1.0 g (8.6 mmol, 1.1 eq.) of 1-ethyl-5-hydroxypyrazole and 1.8 g (8.6 mmol, 1.1 eq.) of N,N'-dicyclohexylcarbodiimide were added. The mixture was stirred at room temperature for 3 hours. Then, 0.8 g (5.9 mmol) of potassium carbonate was added. The mixture was heated at 80° C. for 6 hours. After the completion of the reaction, the solvent was distilled off. The remaining oil was dissolved in ethyl acetate, and end product was extracted with a 5 wt % sodium hydrogencarbonate aqueous solution. The resultant aqueous solution was adjusted to a pH of 1 in an ice bath by adding 2N hydrochloric acid, and extracted with ethyl acetate. An organic layer was washed with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate, and the solvent was distilled off to give 2.0 g (yield 73%) of 4-hydroxy-5-methyl-6-(1-ethyl-5-hydroxypyrazol-4-yl)carbonylthiochroman-1,1-dioxide.

المصدر