تفاعل #1362

معادلة التفاعل

sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine

sodium hydroxide

→

N,N-bis(2,3-epoxypropyl)glycine

المردود 84.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added
2. 2
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure, and 100 ml of ethanol
3. 3
   workup.ADDITIONwere added to the residue
4. 4
   أخرىto separate insoluble matter
5. 5
   ترشيحby filtration
6. 6
   workup.DISTILLATIONThereafter, ethanol was distilled off under reduced pressure

الإجراء التجريبي

A reactor was charged with 20 g (0.07 mole) of sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine obtained in the same manner as in Referential Example 1 and 100 g of water, and the contents were kept at 50° C., to which 35 ml of a 4N aqueous solution of sodium hydroxide were added. After the mixture was stirred for 30 minutes, the solvent was distilled off under reduced pressure, and 100 ml of ethanol were added to the residue to separate insoluble matter by filtration. Thereafter, ethanol was distilled off under reduced pressure, thereby obtaining 11 g (isolation yield: 84%) of N,N-bis(2,3-epoxypropyl)glycine.

المصدر