تفاعل #1361

معادلة التفاعل

water

2-i-butyl-1-hydroxy-4-(1-naphthyl)indene

triethylamine

methanesulfonyl chloride

→

desired product

المردود 93.0%

2-i-butyl-4-(1-naphthyl)indene

المردود 93.0%

المذيبات

methylene chloride

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىA 200-ml three-necked round flask equipped with a stirring bar
2. 2
   workup.ADDITIONTo the mixture was added dropwise a solution
3. 3
   درجة الحرارةwhile cooling with ice bath
4. 4
   workup.ADDITIONAfter the addition
5. 5
   أخرىwas elevated to room temperature
6. 6
   أخرىThereafter, the organic phase was separated
7. 7
   استخلاصthe aqueous phase was extracted with 50 ml of methylene chloride
8. 8
   غسيلwashed with a saturated NaCl aq.
9. 9
   تجفيفby dried over anhydrous Na2SO4
10. 10
    أخرىThe solvent was evaporated under reduced pressure
11. 11
    أخرىThe residue was separated
12. 12
    أخرىpurified with silica gel chromatography (eluting with hexane/ethyl acetate (20/1 parts by volume))

الإجراء التجريبي

A 200-ml three-necked round flask equipped with a stirring bar, a Dimroth condenser, a dropping funnel and a thermometer was charged with 4.54 g (14.4 mmol) of 2-i-butyl-1-hydroxy-4-(1-naphthyl)indene, 5.13 g (50.8 mmol) of triethylamine, 0.10 g (0.82 mmol) of 4-dimethylaminopyridine and 57.7 ml of methylene chloride. To the mixture was added dropwise a solution containing 3.87 ml (33.8 mmol) of methanesulfonyl chloride dissolved in 7.7 ml of methylene chloride under a nitrogen atmosphere while cooling with ice bath. After the addition was completed, the temperature was elevated to room temperature and the mixture was further stirred for 3 hours. The reaction mixture was poured onto 100 ml of water. Thereafter, the organic phase was separated, and the aqueous phase was extracted with 50 ml of methylene chloride. The extracted organic phases were combined and washed with a saturated NaCl aq., followed by dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure. The residue was separated and purified with silica gel chromatography (eluting with hexane/ethyl acetate (20/1 parts by volume)) to obtain 3.98 g of the desired product (mixture of two isomers) as a pale yellow pasty liquid (yield: 93%).

المصدر