تفاعل #1356989

معادلة التفاعل

5-{[4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]oxy}-1H-indazole

→

4-(1H-indazol-5-yloxy)cyclohexanol

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe reaction solution was filtered by the use of Celite
2. 2
   تركيزthe filtrate was concentrated under reduced pressure
3. 3
   أخرىThe resulting residue was purified by a silica gel column chromatography (eluent: chloroform/methanol)

الإجراء التجريبي

An acidic resin (Dowex 50W×8, trade name, Dow Chemical Company, 46 mg) was added to a solution of 5-{[4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]oxy}-1H-indazole (232 mg, 0.733 mmol) in methanol (10 ml), and the resulting mixture was heated to 50° C. After 5 hours, the reaction solution was filtered by the use of Celite and the filtrate was concentrated under reduced pressure. The resulting residue was purified by a silica gel column chromatography (eluent: chloroform/methanol) to obtain 4-(1H-indazol-5-yloxy)cyclohexanol (132 g, 78%).

المصدر