تفاعل #1356912

معادلة التفاعل

Trifluoroacetic acid

tert-butyl 4-(1H-indazol-5-yloxy)-1-piperidinecarboxylate

→

5-(4-piperidinyloxy)-1H-indazole

المردود 52.1%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThen, the solvent of the reaction solution was distilled off under reduced pressure
2. 2
   workup.ADDITIONthe resulting residue was poured into a 1N-aqueous sodium hydroxide solution
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلThe organic layer was washed with a saturated aqueous sodium chloride solution
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

الإجراء التجريبي

Trifluoroacetic acid (0.20 ml, 2.60 mmol) was added to a solution of tert-butyl 4-(1H-indazol-5-yloxy)-1-piperidinecarboxylate (70 mg, 0.221 mmol) in methylene chloride (5 ml) at room temperature and stirred overnight at room temperature. Then, the solvent of the reaction solution was distilled off under reduced pressure and the resulting residue was poured into a 1N-aqueous sodium hydroxide solution and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 5-(4-piperidinyloxy)-1H-indazole (25 mg, 52%).

المصدر