تفاعل #1354128

معادلة التفاعل

sodium 3-methoxy-4-(4′-methylphenylsulfonyloxy)-benzenesulfonate

triphenylsulfonium chloride

→

triphenylsulfonium 3-methoxy-4-(4′-methylphenyl-sulfonyloxy)benzenesulfonate

المردود 56.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic layer was separated
2. 2
   غسيلwashed with 400 g of water
3. 3
   تركيزconcentrated in vacuum
4. 4
   أخرىThe residue, 150 g, was purified by silica gel column chromatography (eluent, dichloromethane/methanol)

الإجراء التجريبي

The sodium 3-methoxy-4-(4′-methylphenylsulfonyloxy)-benzenesulfonate crude product obtained in Synthesis Example 1, 90 g, was added to the aqueous triphenylsulfonium chloride solution obtained in Synthesis Example 2 and 400 g of dichloromethane, which was stirred for one hour at room temperature. The organic layer was separated, washed with 400 g of water, and concentrated in vacuum. The residue, 150 g, was purified by silica gel column chromatography (eluent, dichloromethane/methanol), obtaining the end product, triphenylsulfonium 3-methoxy-4-(4′-methylphenyl-sulfonyloxy)benzenesulfonate as an oily matter in an amount of 69 g (yield 56%).

المصدر