تفاعل #1350576

معادلة التفاعل

3-methoxyphenylacetyl chloride

3-(3-aminophenyl)-4-bromo-1-methylpyrazole

triethylamine

→

title compound

المردود 19.0%

N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl]-2-(3-methoxyphenyl)acetamide

المردود 19.0%

المذيبات

dichloromethane

dichloromethane

brine

ظروف التفاعل

المعالجة

1. 1
   غسيلThe organic layer was washed with more brine
2. 2
   تجفيفthen dried over magnesium sulphate
3. 3
   تركيزconcentrated in vacuo
4. 4
   أخرىThe crude product was purified by column chromatography (ethyl acetate-toluene, 1:1)

الإجراء التجريبي

A solution of 3-methoxyphenylacetyl chloride (0.02 ml, 0.12 mmol) in dichloromethane (0.75 ml) was added dropwise at 0° C. to a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (30 mg, 0.12 mmol) and triethylamine (0.02 ml, 0.13 mmol) in dichloromethane (0.75 ml). The resulting mixture was stirred at room temperature for 16 h and then poured into brine. The organic layer was washed with more brine then dried over magnesium sulphate and concentrated in vacuo. The crude product was purified by column chromatography (ethyl acetate-toluene, 1:1), giving the title compound (9 mg, 19%). Rf 0.30 (ethyl acetate-toluene, 1:1).

المصدر