تفاعل #1350572
ord-1e083b1912e64e0aafd7e1ea671dbe0b
معادلة التفاعل
4-(trifluoromethoxy)benzylamine
triphosgene
3-(3-aminophenyl)4-bromo-1-methylpyrazole
triethylamine
→
title compound
N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][{(4-trifluoromethoxyphenyl)methyl}amino]carboxamide
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1تركيزconcentrated
الإجراء التجريبي
To a stirred solution of triphosgene (12 mg, 0.04 mmol) in CH2Cl2 (0.5 mL) was added dropwise a solution of 3-(3-aminophenyl)4-bromo-1-methylpyrazole (30 mg, 0.12 mmol) and triethylamine (33 μL, 0.24 mmol) in CH2Cl2 (0.5 mL). After 1 h, 4-(trifluoromethoxy)benzylamine (23 mg, 0.12 mmol) was added. The reaction mixture was stirred for 16 h and concentrated. Chromatography on flash silica (75% EtOAc/hexane) gave the title compound as a colourless solid (38 mg, 68%), m.p. 144.6-145.8° C. (EtOAc/hexane).