تفاعل #1350060

معادلة التفاعل

L-tyrosyl-N-(3-phenylpropyl)-D-methioninamide monohydrochloride monohydrate

hydrogen peroxide

→

L-tyrosyl-N-(3-phenylpropyl)-D-methioninamide S-oxide monohydrochloride sesquihydrate

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated under vacuum
2. 2
   أخرىThe residue was reevaporated under vacuum once from ethyl acetate and three times from ether
3. 3
   ترشيحA solution of the residue in water was filtered

الإجراء التجريبي

A solution of L-tyrosyl-N-(3-phenylpropyl)-D-methioninamide monohydrochloride monohydrate (219 mg.) and aqueous hydrogen peroxide (3%, 640 μl) in acetic acid (5 ml.) was stirred at room temperature for two and one quarter hours, then concentrated under vacuum. The residue was reevaporated under vacuum once from ethyl acetate and three times from ether. A solution of the residue in water was filtered and lyophilized, affording as an amorphous white solid L-tyrosyl-N-(3-phenylpropyl)-D-methioninamide S-oxide monohydrochloride sesquihydrate (225 mg.), whose free base is the compound of Formula II wherein Q is Met(O), R1, R2 and R5 are each hydrogen and R4 is (CH2)nY wherein n is 3 and Y is phenyl.

المصدر