تفاعل #1350058

معادلة التفاعل

N-methylmorpholine

pivalyl chloride

N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosine

N-(3-phenylpropyl)-D-methioninamide

N-methylmorpholine

→

[N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosyl]-N-(3-phenylpropyl)-D-methioninamide

المذيبات

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

Ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITwas continued at -20° C. for two hours
3. 3
   أخرىat room temperature
4. 4
   أخرىovernight
5. 5
   غسيلThe mixture was washed three times with saturated aqueous sodium bicarbonate, three times with aqueous citric acid (5%)
6. 6
   تجفيفtwice with water and twice with saturated aqueous sodium chloride, dried over magnesium sulfate
7. 7
   تركيزconcentrated under vacuum
8. 8
   أخرىCrystallization of the residue from ethyl acetate-hexane

الإجراء التجريبي

N-methylmorpholine (485 mg.), then a solution of pivalyl chloride (579 mg.) in tetrahydrofuran (5 ml.), were added to a solution of N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosine in tetrahydrofuran (35 ml.) maintained at -20° C., and the mixture was stirred at that temperature for about 10 minutes. A solution of N-(3-phenylpropyl)-D-methioninamide (1.50 g.) and N-methylmorpholine (485 mg.) in tetrahydrofuran (60 ml.) was then added, and stirring was continued at -20° C. for two hours and then at room temperature overnight. Ethyl acetate (150 ml.) was added. The mixture was washed three times with saturated aqueous sodium bicarbonate, three times with aqueous citric acid (5%), twice with water and twice with saturated aqueous sodium chloride, dried over magnesium sulfate and concentrated under vacuum. Crystallization of the residue from ethyl acetate-hexane afforded as a white solid [N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosyl]-N-(3-phenylpropyl)-D-methioninamide (680 mg.; m.r. 158°-159° C.; [α]D25 +55.4°, c=1 methanol).

المصدر