تفاعل #1350057

معادلة التفاعل

phosphorous pentoxide

N2 (tert-butyloxycarbonyl)-N-(3-phenylpropyl)-D-methioninamide

hydrogen chloride-ethyl acetate

potassium hydroxide

→

N-(3-phenylpropyl)-D-methioninamide hydrochloride

المذيبات

—

ethyl acetate-ether

acetic acid

ظروف التفاعل

الإجراء التجريبي

A solution of N2 -(tert-butyloxycarbonyl)-N-(3-phenylpropyl)-D-methioninamide (1.75 g.) in acetic acid (10 ml.) and hydrogen chloride-ethyl acetate (4 N, 20 ml.) was stirred at room temperature for one hour, then stripped of volatiles under vacuum. A solution of the residue in ethyl acetate-ether was stripped of volatiles under vacuum, finally over phosphorous pentoxide and potassium hydroxide, affording N-(3-phenylpropyl)-D-methioninamide hydrochloride as a vicous oil (1.50 g.).

المصدر