تفاعل #1346031

معادلة التفاعل

DMF

2-bromo-5-iodobenzoic acid

oxalylchloride

→

2-bromo-5-iodo-benzoyl chloride

المردود 100.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter complete addition
2. 2
   أخرىVolatiles were evaporated under reduced pressure

الإجراء التجريبي

To a stirred solution of 2-bromo-5-iodobenzoic acid (25.0 g, 76.48 mmol) in dichloromethane (200 mL) was added oxalylchloride (10.3 mL, 114.74 mmol) at 0° C. followed by DMF (0.9 mL). After complete addition, the reaction mixture was stirred at room temperature for 3 h. Volatiles were evaporated under reduced pressure to furnish 2-bromo-5-iodo-benzoyl chloride (26.4 g). The crude product was used for the next step immediately.

المصدر