تفاعل #1340611

معادلة التفاعل

hydrogen

(3S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-vinylpyrrolidine

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title compound

(3S)-3-(tert-Butoxycarbonyl)amino-4-ethylpyrrolidine

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter filtration
2. 2
   تركيزthe filtrate was concentrated under reduced pressure

الإجراء التجريبي

A 10% palladium carbon catalyst (15 mg) was added to a solution of (3S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-vinylpyrrolidine [an isomer mixture of (4S)-form:(4R)-form (1:4)] (230 mg, 0.66 mmol) in ethanol (8 mL), followed by stirring in a hydrogen atmosphere under an ordinary pressure at room temperature for 12 hours. After filtration, the filtrate was concentrated under reduced pressure, to thereby yield the title compound (an isomer mixture of (4S)-form and (4R)-form (1:4)) as a colorless oily substance (148 mg, 100%).

المصدر