تفاعل #1332467

معادلة التفاعل

4-Bromomethyl-3-(4-chlorophenyl)-2-thia-1-azaspiro[4.5]dec-3-ene 2,2-dioxide

Methylamine

→

3-(4-Chlorophenyl)-4-methylaminomethyl-2-thia-1-azaspiro[4.5]dec-3-ene 2,2-dioxide

المردود 34.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   workup.DISSOLUTIONThe residue was dissolved in CH2Cl2
3. 3
   غسيلwashed with water
4. 4
   استخلاصextracted with 0.5 M HCl
5. 5
   workup.ADDITIONAfter addition of NaOH and extraction with CH2Cl2 the organic layer
6. 6
   تجفيفwas dried (Na2SO4)
7. 7
   أخرىevaporated

الإجراء التجريبي

4-Bromomethyl-3-(4-chlorophenyl)-2-thia-1-azaspiro[4.5]dec-3-ene 2,2-dioxide, made as described in Example 2, (270 mg, 0.69 mmol) was dissolved in ethanol (30 mL). Methylamine (70% solution in water, 8 mL) was added and the mixture was stirred overnight at room temperature and concentrated. The residue was dissolved in CH2Cl2, washed with water and extracted with 0.5 M HCl. After addition of NaOH and extraction with CH2Cl2 the organic layer was dried (Na2SO4) and evaporated to yield 80 mg (34%) of 3-(4-Chlorophenyl)-4-methylaminomethyl-2-thia-1-azaspiro[4.5]dec-3-ene 2,2-dioxide as a solid. MS (IS): 341 [MH]+

المصدر