تفاعل #1328417

معادلة التفاعل

sodium hypochlorite

2-allyl-6-chlorobenzaldehyde oxime

sodium acetate

→

8-Chloro-3a,4-dihydro-3H-indeno[1,2-c]isoxazole

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic phase was separated off
2. 2
   استخلاصthe aqueous phase was extracted with methylene chloride
3. 3
   غسيلthe combined organic phases were washed with saturated ammonium chloride solution
4. 4
   أخرىThe organic phase was dried
5. 5
   أخرىthe solvent was removed

الإجراء التجريبي

At room temperature, 37.0 ml of a sodium hypochlorite solution (12.5% of active chlorine) were added dropwise to a solution of 8.4 g (42.9 mmol) of 2-allyl-6-chlorobenzaldehyde oxime in 100 ml of methylene chloride, and a spatula tip of sodium acetate was added. The mixture was stirred at room temperature for 2 hours, the organic phase was separated off, the aqueous phase was extracted with methylene chloride and the combined organic phases were washed with saturated ammonium chloride solution. The organic phase was dried and the solvent was removed. This gave 7.0 g (94%) of 8-chloro-3a,4-dihydro-3H-indeno-[1,2-c]isoxazole in the form of a viscous oil.

المصدر