تفاعل #1307

معادلة التفاعل

ethyl 4-(4-bromophenyl)butanoate

Compound C

ethyl 4-(4-bromophenyl)butanoate

ethyl (3-bromophenyl)acetate

ethyl 3-bromophenylacetate

Compound B

ethyl 3-bromophenylacetate

→

title compound

Ethyl 4-(3-bromophenyl)butanoate

ظروف التفاعل

الإجراء التجريبي

Employing the same general multistep preparation as for ethyl 4-(4-bromophenyl)butanoate (Compound C), 60 g (246 mmol) of ethyl (3-bromophenyl)acetate (Compound B) was converted into the title compound (oil) using 255 ml (255 mmol) of diisobutyl aluminum hydride (DIBAL-H, 1M in hexane), 85.8 g (250 mmol) of (carbethoxy methylene)triphenylphosphorane and 1.7 g of 10% Pd/C.

المصدر