تفاعل #1283643

معادلة التفاعل

ammonia

4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-6-methylheptanoic acid, ethyl ester

→

amide

4-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-6-methylheptanamide

المذيبات

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرىto rise to room temperature
2. 2
   أخرىThe excess ammonia was removed
3. 3
   أخرىthe solvent evaporated in vacuo

الإجراء التجريبي

A stream of dry ammonia was bubbled at -78° C., through a solution of 0.820 g (2.2 mmol) of 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-6-methylheptanoic acid, ethyl ester in anhydrous diethyl ether (10 mL). After saturation, the temperature was allowed to rise to room temperature with stirring. The excess ammonia was removed, and the solvent evaporated in vacuo. The residue was taken off in pentane to yield the expected amide in quantitative yield as a solid.

المصدر