تفاعل #1275

معادلة التفاعل

sodium hydroxide

sulfuric acid

Trans-1,2-indandiol

acetonitrile

acetonitrile

Water

→

cis-1-amino-2-indanol

المردود 63.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was gradually warmed to 20° C. and aged to 3 hours
2. 2
   درجة الحرارةthe mixture heated to reflux
3. 3
   أخرىThe resulting solid was removed by filtration

الإجراء التجريبي

Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).

المصدر