تفاعل #1269888

معادلة التفاعل

water

5-Amino-2-butylisoindolin-1-one

K2CO3

(2,6-dimethyl-4-phenylpyridin-3-yl)methyl methanesulfonate

→

2-butyl-5-((2,6-dimethyl-4-phenylpyridin-3-yl)methylamino)isoindolin-1-one

المردود 41.3%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture was extracted with EtOAc
2. 2
   غسيلthe combined organic layers were washed with water
3. 3
   تجفيفdried (MgSO4)
4. 4
   أخرىPurification by flash chromatography (DCM/MeOH, gradient 2-8% MeOH)

الإجراء التجريبي

5-Amino-2-butylisoindolin-1-one (63.1 mg, 0.309 mmol), K2CO3 (85 mg, 0.618 mmol) and KI (51.3 mg, 0.309 mmol) were added to a solution of (2,6-dimethyl-4-phenylpyridin-3-yl)methyl methanesulfonate (90 mg, 0.309 mmol) in DMF (6 mL). After stirring overnight, water was added, the mixture was extracted with EtOAc, the combined organic layers were washed with water and dried (MgSO4). Purification by flash chromatography (DCM/MeOH, gradient 2-8% MeOH) provided 2-butyl-5-((2,6-dimethyl-4-phenylpyridin-3-yl)methylamino)isoindolin-1-one (51 mg, 40%).

المصدر