تفاعل #1269885

معادلة التفاعل

NEt3

methanesulphonyl chloride

(2,6-dimethyl-4-phenylpyridin-3-yl)methanol

→

(2,6-dimethyl-4-phenylpyridin-3-yl)methyl methanesulfonate

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with sat. aqueous NaHCO3 solution, water
2. 2
   تجفيفdried (MgSO4)
3. 3
   أخرىRemoval of the solvent

الإجراء التجريبي

NEt3 (0.60 mL, 4.31 mmol) and methanesulphonyl chloride (0.20 mL, 2.59 mmol) were added to a solution of (2,6-dimethyl-4-phenylpyridin-3-yl)methanol (460 mg, 2.16 mmol) in DCM (40 mL) at 0° C. After stirring for 40 min at 0° C. the reaction mixture was diluted with DCM, washed with sat. aqueous NaHCO3 solution, water and dried (MgSO4). Removal of the solvent provided crude (2,6-dimethyl-4-phenylpyridin-3-yl)methyl methanesulfonate which was used without further purification (650 mg).

المصدر