تفاعل #1269863

معادلة التفاعل

4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester

HCl

→

4-(2-Amino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride

المذيبات

Et2O

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe white cake was filtered
2. 2
   غسيلwashed with Et2O
3. 3
   أخرىdried at HV overnight
4. 4
   أخرىThe crude (1.19 g) was used without purification

الإجراء التجريبي

To a solution of 4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester (1.79 g, as described in WO2008044217) in CH2Cl2 (22 mL) was added HCl (4M in dioxane, 8.3 mL) and the reaction mixture was stirred for 2 h at RT. The suspension was diluted with Et2O (1000 mL) and the white cake was filtered, washed with Et2O and dried at HV overnight. The crude (1.19 g) was used without purification.

المصدر