تفاعل #1269860

معادلة التفاعل

suspension

4-((S)-4-Carboxy-2-{[5-((E)-2-carboxy-vinyl)-2-phenyl-thiazole-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid butyl ester

→

desired product

المردود 33.8%

4-((S)-4-Carboxy-2-{[5-(2-carboxy-ethyl)-2-phenyl-thiazole-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid butyl ester

المردود 33.8%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtrated over celite
2. 2
   أخرىthe filtrate evaporated to dryness

الإجراء التجريبي

A suspension of Example 19 (53 mg) and Pd/C (10%, 62 mg) in MeOH (2 mL) was stirred at RT under H2 atmosphere until reaction completion. The reaction mixture was filtrated over celite and the filtrate evaporated to dryness. Preparative HPLC (I) gave 18 mg of the desired product as yellow foam.

المصدر