تفاعل #1269858

معادلة التفاعل

4-((S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester

→

desired compound

المردود 94.9%

4-((S)-2-Amino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester

المردود 94.9%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered through celite
2. 2
   أخرىevaporated off
3. 3
   أخرىHV drying

الإجراء التجريبي

A suspension of 4-((S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester (4.00 g, prepared as described in WO2008050301) and Pd/C (5%, 0.42 g) in EtOH (15 mL) was hydrogenated at RT overnight. The reaction mixture was then stirred under H2 overnight. The mixture was filtered through celite and evaporated off. HV drying afforded the desired compound as light brown oil (2.79 g).

المصدر