تفاعل #1269852

معادلة التفاعل

4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester

2-phenyl-1,3-thiazole-4-carboxylic acid

DIPEA

TBTU

→

desired product

المردود 49.0%

4-{2-[(2-Phenyl-thiazole-4-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid ethyl ester

المردود 49.0%

المذيبات

DMF

DMF

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction mixture was directly purified by preparative HPLC (IV)

الإجراء التجريبي

To a solution of 2-phenyl-1,3-thiazole-4-carboxylic acid (5.1 mg) and DIPEA (3 eq) in DMF (0.4 mL) was added TBTU (1.2 eq) in DMF (0.2 mL). Then, a solution of 4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester (5.4 mg, prepared as described in WO2006114774) in DMF (0.2 mL) was added. After stirring overnight at RT, the reaction mixture was directly purified by preparative HPLC (IV) to give 4.9 mg of the desired product.

المصدر