تفاعل #1269843

معادلة التفاعل

DBU

BOP

3-Methyluracil

(1R,2R)-(−)-2-hydroxycyclopentylamine hydrochloride salt

→

product

المردود 76.5%

2-((1R,2R)-2-hydroxycyclopentylamino)-3-methylpyrimidin-4(3H)-one

المردود 76.5%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature overnight
2. 2
   أخرىThe reaction mixture was purified by a semi-preparative HPLC

الإجراء التجريبي

3-Methyluracil (12.6 mg, 0.1 mmol) was dissolved in 0.5 mL of DMF, and then BOP (71 mg, 0.16 mmol) was added. The mixture was stirred at room temperature for two minutes, then (1R,2R)-(−)-2-hydroxycyclopentylamine hydrochloride salt (22 mg, 0.16 mmol) was added, followed by DBU (51 uL, 3.4 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was purified by a semi-preparative HPLC to give pure product (16 mg, yield 76%). MS (ESI) m/z 210.1 [M+H]+.

المصدر