تفاعل #1269839

معادلة التفاعل

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

المذيبات

piperidine

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture is concentrated under vacuum, water
2. 2
   workup.ADDITIONis added to the residue
3. 3
   استخلاصthe product is extracted with ethyl acetate
4. 4
   أخرىThe crude product is purified by conversion into its hydrochloride salt

الإجراء التجريبي

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) is dissolved in 20% piperidine in dimethylformamide at 0° C. The solution is continued stifling for 1 h. The reaction mixture is concentrated under vacuum, water is added to the residue, and the product is extracted with ethyl acetate. The crude product is purified by conversion into its hydrochloride salt.

المصدر