تفاعل #1269838

معادلة التفاعل

ethyl acrylate

ethyl glycinate hydrochloride

sodium hydroxide

→

Diethyl-2-azabutane-1,4-dicarboxylate

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter 19 h the solution is partitioned with dichloromethane (3×100 mL)
2. 2
   تجفيفThe organic layer is dried with anhydrous sodium sulfate
3. 3
   ترشيحfiltered
4. 4
   أخرىevaporated
5. 5
   workup.DISTILLATIONThe residue is distilled
6. 6
   أخرىto afford AA (28.8 g, 61%)

الإجراء التجريبي

A 4.7 M aqueous solution of sodium hydroxide (50 mL) is added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) is added and the mixture is stirred at room temperature until completion of the reaction is ascertained by TLC. After 19 h the solution is partitioned with dichloromethane (3×100 mL). The organic layer is dried with anhydrous sodium sulfate, filtered and evaporated. The residue is distilled to afford AA (28.8 g, 61%).

المصدر