تفاعل #1269175

معادلة التفاعل

N-methyl amine

8-bromo-6-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid

8-Bromo-6-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide

8-bromo-4-methylamino-6-methoxy-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide

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title compound

6-Methoxy-4-methylamino-8-(4-methyl-piperazin-1-yl)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide

ظروف التفاعل

المعالجة

1. 1
   أخرىA glassy orange solid was obtained

الإجراء التجريبي

The title compound was prepared from 8-bromo-6-methoxy-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid (Reference Example 27b) according to the procedure described for Example 98 using N-methyl amine to prepare 8-bromo-4-methylamino-6-methoxy-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)-amide. A glassy orange solid was obtained. Mass Spec.: calc. for [C27H34N6O3+H]+ Theor. m/z=491; Obs.=491.5.

المصدر