تفاعل #1265389

معادلة التفاعل

5-Chloro-2-(1,1-dimethoxy-ethyl)-thiazole

trifluoroacetic acid

water

→

sub-titled compound

1-(5-Chloro-thiazol-2-yl)-ethanone

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated to an oil
2. 2
   workup.ADDITIONdiluted with diethyl ether
3. 3
   غسيلwashed with 10% sodium bicarbonate, water and brine
4. 4
   تجفيفdried (magnesium sulfate)
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated

الإجراء التجريبي

To a solution of 5-Chloro-2-(1,1-dimethoxy-ethyl)-thiazole (3.5 g) in dichloromethane (20 ml) was added trifluoroacetic acid (30 ml) and water (1 ml). The resulting mixture was stirred overnight at ambient, concentrated to an oil, diluted with diethyl ether, washed with 10% sodium bicarbonate, water and brine, dried (magnesium sulfate), filtered and concentrated to afford the sub-titled compound as a yellow solid in quantitative yield (2.6 g); 1H NMR (400 Mhz, CDCl3) δ 2.7 (3H, s), 7.8 (1H, s).

المصدر