تفاعل #1258

معادلة التفاعل

(-)-2-(4-(3-hydroxy-4,4,4-trifluoro-1-butenyl) phenyl)-5-decyloxypyrimidine

→

(-)-2-(4-(3-butoxy-4,4,4-trifluoro-1-butenyl)phenyl)-5-decyloxypyrimidine

المردود 173.7%

المذيبات

butyl iodide

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was cleared of silver oxide by filtration
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   أخرىthe residue was purified by silica gel column chromatography

الإجراء التجريبي

1.0 g of (-)-2-(4-(3-hydroxy-4,4,4-trifluoro-1-butenyl) phenyl)-5-decyloxypyrimidine was dissolved in 5 ml of butyl iodide. The solution was added with 3 g of silver oxide and stirred at 25°-30° C. for 4 days. The reaction mixture was cleared of silver oxide by filtration and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography using toluene/ethyl acetate as eluent to obtain 0.98 g of (-)-2-(4-(3-butoxy-4,4,4-trifluoro-1-butenyl)phenyl)-5-decyloxypyrimidine.

المصدر