تفاعل #1256714

معادلة التفاعل

11

4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine

12

2,6-di-tert-butyl-4-vinyl-phenol

PPh3

→

title compound

المردود 91.2%

2,6-di-tert-butyl-4-{2-[4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl]-vinyl}-phenol

المردود 91.2%

ظروف التفاعل

المعالجة

1. 1
   أخرىevacuated
2. 2
   workup.ADDITIONNext, dry Et3N (10 mL) was added under an N2 flow
3. 3
   أخرىthe mixture was degassed by 3 freeze-thaw cycles
4. 4
   درجة الحرارةThe reaction mixture was then cooled to room temperature
5. 5
   workup.ADDITIONdiluted with methylene chloride (50 mL)
6. 6
   ترشيحfiltered through a thin pad of silica gel
7. 7
   تركيزconcentrated in vacuo
8. 8
   أخرىto afford a red solid
9. 9
   أخرىThe crude product was purified by flash chromatography on silica gel
10. 10
    غسيلeluting with 3:1 hexane

الإجراء التجريبي

A flame-dried sealable Schlenk tube was charged with 11 (1.69 g, 5.0 mmol), 12 (2.32 g, 10.0 mmol), Pd(OAc)2 (112 mg, 0.50 mmol), and PPh3 (131 mg, 0.50 mmol), evacuated, and then backfilled with N2. Next, dry Et3N (10 mL) was added under an N2 flow. The Schlenk tube was next sealed, the mixture was degassed by 3 freeze-thaw cycles, and backfilled with N2. The Schlenk tube was then wrapped with aluminum foil and stirred at 100° C. for 36 h. The reaction mixture was then cooled to room temperature, diluted with methylene chloride (50 mL), filtered through a thin pad of silica gel, and concentrated in vacuo to afford a red solid. The crude product was purified by flash chromatography on silica gel, eluting with 3:1 hexane: ethyl acetate to give the title compound 2.01 g (91.2%) as a colorless solid: mp 234-235° C.; 1H NMR (400 MHz, CDCl3): δ 8.402 (s, 2H), 7.371 (s, 2H), 7.307 (s, 2H), 7.133 (d, 1H, J=16.4 Hz), 6.936 (d, 1H, J=16.0 Hz), 5.331 (s, 1H), 1.951 (s, 6H), 1.911 (s, 6H), 1.499 (s, 18H); 13C NMR (100 MHz, CDCl3): δ 153.971, 148.630, 148.502, 137.347, 136.301, 135.928, 134.817, 131.251, 129.595, 128.876, 125.837, 125.709, 123.598, 34.638, 30.534, 19.997, 16.822; HRMS (EI): m/z 441.3023 [M+]; calcd, 441.3032; Anal. Calcd. for C31H39NO·H2O: C, 81.00; H, 8.99; N, 3.05. Found; C, 81.01; H, 8.64; N, 3.02.

المصدر