تفاعل #1256

معادلة التفاعل

sodium borohydride

2-(4-acetylphenyl)-5-decyloxypyrimidine

ethanol

chloroform

→

2-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine

المردود 100.3%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىequipped with a stirrer
2. 2
   أخرىThe resulting reaction mixture
3. 3
   استخلاصfollowed by extraction and liquid separation
4. 4
   غسيلthe obtained chloroform layer was washed with water
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

35.5 g (0.1 mo1) of 2-(4-acetylphenyl)-5-decyloxypyrimidine, 300 ml of ethanol and 300 ml of chloroform were supplied into a four-necked flask equipped with a stirrer and a thermometer. Then 2.8 g (0.075 mol) of sodium borohydride was added at 30°-40° C. and the mixture was stirred at the same temperature for 4 hours. The resulting reaction mixture was poured into 500 ml of water, followed by extraction and liquid separation, and the obtained chloroform layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 35.8 g of 2-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine (II-c-11) (yield: 100%).

المصدر