تفاعل #1255061

معادلة التفاعل

KOH

7-(2-methylallyloxy)-8-acetyl-3-methylflavone

3,4,5-trimethoxy-benzaldehyde

→

product

المردود 60.8%

1-[3-Methyl-7-(2-Methylallyloxy)Flavon-8-yl]-3-(3,4,5-Tri-Methoxyphenyl)-Propen-1-one

المردود 60.8%

المذيبات

ethanol

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONthe addition
2. 2
   workup.WAITThe reaction is left
3. 3
   workup.STIRRINGunder stirring for one night
4. 4
   أخرىthe precipitate is separated by filtration
5. 5
   أخرىdried under vacuum
6. 6
   أخرىThe compound is crystallized by methanol

الإجراء التجريبي

A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(2-methylallyloxy)-8-acetyl-3-methylflavone (2.61 g, 0.0075 mol) and 3,4,5-trimethoxy-benzaldehyde (1.47 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.4 g of product m.p. 82-84° C., 1H-NMR (CDCl3) δ:1.76 (s, 3H); 2.20 (s, 3H); 3.82 (s, 3H); 4.62 (s, 2H); 5.05 (d, 2H, J=18 Hz); 6.95-7.10 (m, 3H); 7.09 (d, 1H); 7.10 (d, 1H, J=9 Hz); 7.31 (d, 1H, J=16 Hz); 7.40-7.45 (m, 3H); 7.55-7.58 (m, 2H); 7.31 (s, 2H); 8.32 (d, 1H, J=8.9 Hz).

المصدر