تفاعل #1253196

معادلة التفاعل

3-Fluoro-4-(4-{2-fluoroethyl}-3-oxopiperazin-1-yl)nitrobenzene

→

5-amino-2-[4-(2-fluoroethyl)-3-oxopiperazin-1-yl]fluorobenzene

المذيبات

ethyl acetate

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solution flushed with argon
2. 2
   workup.ADDITIONPalladium (10% on carbon, 200 mg) is added
3. 3
   ترشيحthe mixture is filtered through celite and solvent
4. 4
   أخرىremoved
5. 5
   غسيلwashed twice with water
6. 6
   تجفيفdried over magnesium sulfate
7. 7
   أخرىthe solvent is removed

الإجراء التجريبي

3-Fluoro-4-(4-{2-fluoroethyl}-3-oxopiperazin-1-yl)nitrobenzene (4.35 g) is dissolved in a mixture of ethyl acetate (250 ml) and DMF (5 ml), and the solution flushed with argon. Palladium (10% on carbon, 200 mg) is added and the mixture hydrogenated under ambient pressure. After gas uptake had ceased, the mixture is filtered through celite and solvent removed. The residue is taken up in ethyl acetate, washed twice with water, dried over magnesium sulfate and the solvent is removed to give 5-amino-2-[4-(2-fluoroethyl)-3-oxopiperazin-1-yl]fluorobenzene which is used without further purification.

المصدر