تفاعل #1247952

معادلة التفاعل

hydrochloric acid

6-chloro-2-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide

dimethylamine

t-butanol

→

title compound

6-dimethylamino-2-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.WAITThe reaction solution was left
2. 2
   درجة الحرارةcooled to room temperature
3. 3
   أخرىto precipitate crystals which
4. 4
   ترشيحwere then filtered
5. 5
   غسيلwashed with water

الإجراء التجريبي

A mixture of 6-chloro-2-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide (0.50 g, 1.81 mmol), 50% aqueous dimethylamine (1.0 ml) and t-butanol (5.0 ml) was heated at 100° C. for 8 hours with stirring in a sealed tube reactor. The reaction solution was left and cooled to room temperature, poured into water (50.0 ml) and adjusted to pH 6 with dilute hydrochloric acid, to precipitate crystals which were then filtered and washed with water, to give the title compound as pale yellow crystals. The yield was 0.38 g (74.0%).

المصدر