تفاعل #1245965

معادلة التفاعل

3-tert-butyl-phenol

2-(2-bromo-ethyl)-[1,3]dioxane

potassium carbonate

→

2-[2-(3-tert-butyl-phenoxy)-ethyl]-[1,3]dioxane

المردود 112.3%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 16 hours
2. 2
   درجة الحرارةAfter cooling
3. 3
   أخرىthe solvent was removed under reduced pressure
4. 4
   أخرىthe residue partitioned between diethyl ether and water
5. 5
   غسيلThe isolated organic layer was washed with water
6. 6
   تجفيفdried with magnesium sulfate
7. 7
   ترشيحfiltered
8. 8
   أخرىthe solvent removed under reduced pressure

الإجراء التجريبي

3-tert-butyl-phenol (1.50 g, 10 mmol), 2-(2-bromo-ethyl)-[1,3]dioxane (1.38 g, 10 mmol) and potassium carbonate (2.15 g, 11 mmol) in 20 ml acetonitrile was heated to reflux for 16 hours. After cooling, the solvent was removed under reduced pressure and the residue partitioned between diethyl ether and water. The isolated organic layer was washed with water, dried with magnesium sulfate, filtered and the solvent removed under reduced pressure to give 2.97 g of crude 2-[2-(3-tert-butyl-phenoxy)-ethyl]-[1,3]dioxane, which was used without further purification.

المصدر