تفاعل #1244273

معادلة التفاعل

2-phenyl-1,3-dioxan-5-ol

triethyl amine

tosyl chloride

→

white solid

المردود 96.0%

2-Phenyl-1,3-dioxan-5-yl 4-methylbenzenesulfonate

المردود 96.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe reaction was poured onto water (800 mL)
2. 2
   استخلاصextracted into DCM
3. 3
   تركيزconcentrated to dryness
4. 4
   أخرىThe crude mixture was recrystallized from EtOAc

الإجراء التجريبي

To a 2 liter round bottom flask was added 2-phenyl-1,3-dioxan-5-ol (50 g, 277 mmol), triethyl amine (42.1 g, 416 mmol), DMAP (3.39 g, 27.7 mmol) and dichloromethane (1 L). The reaction was cooled to 0° C. To this solution was added tosyl chloride (58.2 g, 305 mmol) and the reaction was stirred overnight at RT. The reaction was poured onto water (800 mL) and extracted into DCM. The organic layers were combined and concentrated to dryness. The crude mixture was recrystallized from EtOAc:Hex to afford 88 g (96% yield) of a white solid. 1H NMR (CDCl3, 400 MHz), δ: 2.44 (3H, s), 4.09 (2H, dd, J=13.6, 2 Hz), 4.27 (2H, dd, J=13.6, 1.6 Hz), 4.51 (2H, pseudo t, J=1.6 Hz), 7.33-7.36 (5H, m), 7.44-7.45 (2H, m), 7.85 (2H, d, J=8.39 Hz). Mass Spec (lo-res): Calc'd for C17H18O5S: 334.09. found: 335.1 (M+H).

المصدر