تفاعل #1244271

معادلة التفاعل

alkyne

2-Bromo-N-(prop-2-ynyl)acetamide

2-nitroimidazole

2-Nitro-1-(prop-2-ynyl)-1H-imidazole

K2CO3

→

white solid

المردود 18.0%

2-(2-Nitro-1H-imidazol-1-yl)-N-(prop-2-ynyl)acetamide

المردود 18.0%

المذيبات

DMF

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe resultant precipitate (1.2 g) was filtered off
2. 2
   غسيلwashed with water (2×40 mL)
3. 3
   استخلاصThe aqueous layer was extracted into EtOAc
4. 4
   تركيزThe organic layer was concentrated to dryness
5. 5
   أخرىThe material was purified on a silica gel cartridge

الإجراء التجريبي

To a round bottom flask was added alkyne 18 (1.56 g, 8.84 mmol), 2-nitroimidazole 10 (1 g, 8.84 mmol) and K2CO3 (1.22 g, 8.84 mmol) in DMF (10 mL). The reaction was stirred overnight. The reaction was diluted with water (100 mL) and the resultant precipitate (1.2 g) was filtered off and washed with water (2×40 mL). The aqueous layer was extracted into EtOAc. The organic layer was concentrated to dryness and combined with the precipitate. The material was purified on a silica gel cartridge using EtOAc:Hex as the eluent to afford a 19 white solid (324 mg, 18%). Mass Spec (lo-res): Calc'd for C8H8N4O3: 208.06; found: 209.10 (M+H).

المصدر