تفاعل #1244263

معادلة التفاعل

alcohol

2-(4-((2-Nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)ethanol

Ts2O

→

12

المردود 53.1%

2-(4-((2-Nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)ethyl 4-methylbenzenesulfonate

المردود 53.1%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction was concentrated in vacuo
2. 2
   أخرىpurified on a silica gel cartridge

الإجراء التجريبي

To a round bottom flask containing alcohol 11 (160 mg, 0.672 mmol), TEA (136 mg, 1.34 mmol) and DCM (5 mL) was added Ts2O (263 mg, 0.806 mmol). The reaction was stirred at RT for 4 hrs. TLC indicated that the reaction was complete. The reaction was concentrated in vacuo and purified on a silica gel cartridge using EtOAc:Hex as the eluent to afford 140 mg (53% yield) of 12 as a pale orange oil. Mass Spec (lo-res): Calc'd for C15H16N6O5S: 392.092. found: 393.10 (M+H).

المصدر