تفاعل #1244036

معادلة التفاعل

methyl 5-chloroanthranilate

3,4,5-trimethoxybenzoylchloride

triethylamine

→

methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate

المردود 52.6%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder cooling
2. 2
   درجة الحرارةheated
3. 3
   درجة الحرارةunder reflux for 1 hour
4. 4
   تركيزThe reaction mixture is concentrated under reduced pressure and to the residue
5. 5
   workup.ADDITIONis added water
6. 6
   ترشيحThe precipitated crystals are collected by filtration
7. 7
   أخرىrecrystallized from a mixture of chloroform and ether

الإجراء التجريبي

To a solution of 1.3 g of methyl 5-chloroanthranilate and 1.8 g of 3,4,5-trimethoxybenzoylchloride in 30 ml of tetrahydrofuran is added 1.5 g of triethylamine under cooling, and the mixture is stirred at room temperature for 2 hours and then heated under reflux for 1 hour. The reaction mixture is concentrated under reduced pressure and to the residue is added water. The precipitated crystals are collected by filtration and recrystallized from a mixture of chloroform and ether to obtain 1.4 g of methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate as colorless prisms.

المصدر